Vitamin D supplementation does not significantly reduce the likelihood of developing type 2 diabetes in individuals with adequate levels of vitamin D but at high risk for the disease, a six-year nationwide diabetes prevention clinical trial that included a study site at the University of Tennessee Health Science Center concluded recently.

Observational studies had indicated vitamin D might prevent the development of type 2 diabetes, but this had not been previously tested in a clinical trial, said Karen C. Johnson, MD, MPH, chair of the Department of Preventive Medicine at UTHSC and College of Medicine Endowed Professor in Women’s Health.

The Vitamin D and Type 2 diabetes (D2d) study released its findings at the American Diabetes Association’s 79th Scientific Sessions in San Francisco in early June.

According to the Centers for Disease Control and Prevention, more than 100 million adults in the United States are now living with diabetes or prediabetes.

Funded by The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health (NIH), the D2d study enrolled 2,423 people with impaired glucose tolerance but without a diagnosis of diabetes from 22 centers across the country. It was coordinated by the Division of Endocrinology at Tufts Medical Center in Boston.

The Memphis site enrolled and followed 32 individuals through the course of the study that began in 2013. Catherine Womack, MD, associate professor in the Department of Preventive Medicine and co-chief of the Division of Internal Medicine in the College of Medicine, was a co-investigator at the UTHSC site.

Participants were given 4,000 international units of vitamin D per day or a matching placebo. They received blood tests twice a year for an average of two-and-a-half years to monitor for the development of diabetes. Those receiving vitamin D showed no negative effects from the supplementation, however, the vitamin D did not reduce the risk of diabetes by the target level of 25 percent or more in the total study population.

In an exploratory analysis, a very small group of D2d participants with extremely low levels of vitamin D did show a reduced risk of developing the disease, but because their numbers in the study were few, they did not appear to influence the study outcome.

Knowing your Vitamin D level may be important in understanding your risk, the researchers concluded.

Johnson applauds local and national participants in the D2d study, as well as in the many other clinical trials ongoing at UTHSC. “Participation by people in the community in research is very important because without these participants, we couldn’t find out important things like this,” she said.

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